Ethanolic extract of Geastrum saccatum (Basidiomycota: Geastraceae) has inhibitory power in the development of strains of Candida spp.?
Resumo
Due to the appearance of isolated resistant cases of Candida spp. to known antifungal drugs, there is a demand and concern in finding and testing new substances for the treatment of candidiasis. This study aimed to evaluate the inhibitory potential of the Geastrum saccatum fungus over some species of Candida. In this study, we tested ethanolic extracts of basidiomas of the species Geastrum saccatum (Basidiomycota: Geastraceae), collected in an area of Environmental Preservation belonging to the UniEVANGÉLICA University Center of Anápolis, located in the city of Anápolis, against Candida albicans, Candida parapsilosis and Candida tropicalis. The analysis on inhibitory activity was performed by means of macrodilution test and plaque sensibility test in cells of C. parapsilosis, C. albicans and C. tropicalis, subjected to concentrations of 2%, 1% and 0,5% of ethanolic extract of G. saccatum. According to obtained results, in different concentrations of ethanolic extract of G. saccatum added to plates containing C. albicans, C. parapsilosis and C. tropicalis, it was not possible to observe any inhibition of the growth of the fungus. In macrodilution tests there was also no inhibition of the growth of C. albicans, C. parapsilosis and C. tropicalis by the fungus G. saccatum in any of the tested concentrations, making it impossible to determine the minimum inhibitory concentration. Both tests were confirmatory for the negativity of antifungal potential of G. saccatum on Candida species.
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